最近の発表論文

応用生物プロセス学講座 > 最近の発表論文

最近の発表論文　[Publications]

| 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 |
| 2007 | 2008 | 2009 | 2010 | 2011 | 2012 |2013 |2014 | 2015 |2016 |2017 |2018 |

【1997年】

  1. N. Itoh, Volatile Haligenated Compounds from Marine Algaem: Their Formation Mechanisms and Geochemical Aspects, Recent. Res. Devel. in Phytochem., 1, 309-327 (1997).
  2. N. Itoh, M. Tujita, T. Ando, G. Hisatomi and T. Higashi, Formation and Emission of Monohalomethanes from Marine Algae, Phytochemistry, 45, 67-73 (1997).
  3. N. Itoh, R. Morihama, J.-C. Wang, K. Okada and N. Mizuguchi, Purification and Characterization of Phenylacetaldehyde Reductase from a Styrene-assimilating Corynebacterium Strain ST-10, Appl. Environ. Microbiol., 63, 3783-3788 (1997).
  4. N. Itoh, K. Hayashi, T. Ito, N. Mizuguchi and K. Okada, Characterization of Styrene Oxide Isomerase, a Key Enzyme of Styrene and Styrene Oxide Metabolism in Corynebacterium sp., Biosci. Biotech. Biochem., 61, 2058-2062 (1997).
  5. J. Miura and N. Itoh, Determination of Vanadium, Cobalt, Nickel and Iron in Bromoperoxidaes from Corallina pilulifera and Pseudomonas putida by High Performance Liquid Chromatography with Spectrophotometric Detection, J. Liq. Chromato., 20, 2367-2376 (1997).
  6. T. Dairi, Y. Hamano, Y. Igarashi, T. Furumai and T. Oki, Protoplasting and Regeneration of Strains Belonging to the Genus Actinomadura, Actinomycetol., 11, 1-5 (1997).
  7. J. Q. Liu, T. Dairi, M. Kataoka, S. Shimizu and H. Yamada, L-allo-Threonine Aldolase from Aeromonas jandaei DK-39: Gene Cloning, Nucleotide Sequencing, and Identification of the Pyridoxal 5'-Phosphate-binding Lysine Residue by Site-directed Mutagenesis, J. Bacteriol., 179, 3555-3560 (1997).
  8. J. Q. Liu, S. Nagata, T. Dairi, H. Misono, S. Shimizu and H. Yamada, The GLY1 Gene of Saccharomyces cerevisiae Encodes a Low Specific L-Threonine Aldolase that Catalyzes Cleavage of L-Threonine and L-allo-Threonine to Glycine: Expression of the Gene in Escherichia coli and Purification and Characterization of the Enzyme, Eur. J. Biochem., 245, 289-293 (1997).
  9. T. Dairi, Y. Hamano, Y. Igarashi, T. Furumai and T. Oki, Cloning and Nucleotide Sequence of the Putative Polyketide Synthase Genes for Pradimicin Biosynthesis from Actinomadura hibisca, Biosci. Biotech. Biochem., 61, 1445-1453 (1997).

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【1998年】

  1. J. Q. Liu, S. Ito, T. Dairi, N. Itoh, M. Kataoka, S. Shimizu, and H. Yamada, Gene Cloning, Nucleotide Sequencing, and Purification and Characterization of the Low-specificity L-Threonine Aldolase from Pseudomonas sp. Strain NCIMB10558. Appl. Environ. Microbiol., 64, 549-554 (1998).
  2. J. Q. Liu, S. Ito, T. Dairi, N. Itoh, S. Shimizu and H. Yamada, Low-specificity L-Threonine Aldolase of Pseudomonas sp. NCIMB 10558: Purification, Characterization and its Application to Beta-hydroxy-alpha-amino Acid Synthesis. Appl. Microbiol. Biotechnol., 49, 702-708 (1998).
  3. J. Q. Liu, T. Dairi, N. Itoh, M. Kataoka, S. Shimizu and H. Yamada, Gene Cloning, Biochemical Characterization and Physiological Role of a Thermostable Low-specificity L-Threonine Aldolase from Escherichia coli. Eur. J. Biochem., 254, 220-226 (1998).
  4. J. Q. Liu, T. Dairi, N. Itoh, M. Kataoka, S. Shimizu and H. Yamada, A Novel Metal-activated Pyridoxal Enzyme with a Unique Primary Structure, Low Specificity D-Threonine Aldolase from Arthrobacter sp. Strain DK-38. Molecular Cloning and Cofactor Characterization. J. Biol. Chem., 273, 16678-16685 (1998).
  5. S. Matsumoto, H. Yukitake, N. Ohara, T. Dairi, H. Kanbara and T. Yamada, Shotgun Cloning and Characterization of the Thymidylate Synthase-Encoding Gene from Mycobacterium bovis BCG, Microbiol. Immunol., 42, 15-21 (1998).
  6. K. L. Britton, H. F. Rogers, Y. Asano, T. Dairi, Y. Kato, T. J. Stillman and D. W. Rice, Crystallization of Arthrobacter sp. Strain 1C N-(1-D-Carboxyethyl)-L-norvaline Dehydrogenase and its Complex with NAD+, Acta Cryst., D54, 124-126 (1998).

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【1999年】

  1. M. Wada, T. Matsumoto, S. Nakamori, M. Sakamoto, M. Kataoka, J.-Q. Liu, N. Itoh, H. Yamada and S. Shimizu, Purification and Characterization of a Novel Enzyme, L-Threo-3-hydroxyaspartate Dehydratase from Pseudomonas sp. T62, FEMS MIcrobiol. Lett., 179, 147-151 (1999).
  2. J. C. Wang, M. Sakakibara, J.Q. Liu, T. Dairi and N. Itoh, Cloning, Sequence Analysis, and Expression in Escerichia coli of the Gene Encoding Phenylacetaldehyde Reductase from Styrene-assimilating Corynebacterium sp. Strain ST-10. Appl. Microbiol. Biotechnol., 52, 386-392 (1999).
  3. J. Q. Liu, M. Odani, T. Dairi, N. Itoh, S. Shimizu and H. Yamada, A New Route to L-Threo-3-[4-(methylthio)phenylserine], a Key Intermediate for the Synthesis of Antibiotics: Recombinant Low-specificity D-Threonine Aldolase-catalyzed Stereospecific Resolution. Appl. Microbiol. Biotechnol., 51, 586-591 (1999).
  4. N. Itoh, Y. Tujibata and J.-Q. Liu, Cloning and Overexpression in Escherichia coli of the Gene Encoding Dihydroxyacetone Kinase Isoenzyme I from Schizosaccharomyces pombe, and its Application to Dihysroxyacetone Phosphate Production, Appl. Microbiol. Biotechnol., 51, 193-200 (1999).
  5. N. Itoh, N. Mizuguchi and M. Mabuchi, Production of Chiral Alcohols by Enantioselective Reduction with NADH-dependendt Phenylacetaldehyde Reducatse from Corynebacterium strain, ST-10, J. Mol. Catal. :B, 6, 41-50 (1999).
  6. J.C.-Wang, M. Sakakibara, M. Matsuda and N. Itoh, Site-directed Mutagenesis of Two Zinc-binding Centers of the NADH-dependent Phenylacetaldehyde Reductase from Styrene-assimilating Corynebacterium sp. strain ST-10, Biosci. Biotechnol. Biochem., 63, 2216-2218 (1999).
  7. T. Dairi, Y. Hamano, T. Furumai and Toshikazu Oki, Development of a Self-cloning System for Actinomadura verrucosospora and Identification of Polyketide Synthase Genes Essential for Production of the Angucyclic Antibiotic Pradimicin, Appl. Environ. Microbiol., 65, 2703-2709 (1999).

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【2000年】

  1. T. Dairi, Y. Motohira, T. Kuzuyama, S. Takahashi, N. Itoh and H. Seto, Cloning of the Gene Encoding 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase from Terpenoid Antibiotics-Producing Stereptomyces Strains, Mol. Gen. Genet., 262, 957-964 (2000).
  2. J. Q. Liu, M. Odani, T. Yasuoka, T. Dairi, N. Itoh, M. Kataoka, S. Shimizu and H. Yamada, Gene Cloning and Overproduction of Low-specificity D-Threonine Aldolase from Alcaligenes xylosoxidans and its Application for Production of a Key Intermediate for Parkinsonism Drug, Appl. Microbiol. Biotechnol., 54, 44-51 (2000).
  3. N. Itoh, C. Yachi and T. Kudome, Determining a Novel NAD+-dependent Amine Dehydrogenase with a Broad Substrate Range from Streptomyces virginiae IFO 12827: Purification and Characterization, J. Mol. Cat. :B, 10, 281-290 (2000).
  4. T. Kuzuyama, M. Takagi, K. Kaneda, T. Dairi and H. Seto, Formation of 4-(Cytidine 5'-iphospho)-2-C-methyl-D-erythritol from 2-C-Methyl-D-erythritol 4-phosphate by 2-C-Methyl-D-erythritol 4-phosphate Cytidylyltransferase, A New Enzyme in the Nonmevalonate Pathway, Tetrahedron Lett., 41, 703-706 (2000).
  5. T. Kuzuyama, M. Takagi, K. Kaneda, H. Watanabe, T. Dairi and H. Seto, Studies on the Nonmevalonate Pathway: Conversion of 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol to its 2-Phospho Derivative by 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol Kinase, Tetrahedron Lett., 41, 2925-2928 (2000).
  6. M. Takagi, T. Kuzuyama, K. Kaneda, H. Watanabe, T. Dairi and H. Seto, Studies on the Nonmevalonate Pathway: Formation of 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate from 2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, Tetrahedron Lett., 41, 3395-3398 (2000).

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【2001年】

  1. Y. Hamano, T. Dairi, M. Yamamoto, T., Kawasaki, K., Kaneda, T. Kuzuyama, N. Itoh and H. Seto, Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces strain, Biosci. Biotech. Biochem., 65, 1627-1635 (2001).
  2. N. Itoh, T. Kawanami, J. Q. Liu, T. Dairi, M. Miyakoshi, C. Nitta and Y. Kimoto, Cloning and Biochemical Characterization of Co2+-Activated Bromoperoxidase-esterase (Perhydrolase) from Pseudomonas putida, Biochimica. Biophysica. Acta, 1545, 53-66 (2001).
  3. N. Ohsawa, Y. Ogata, N. Okada and N. Itoh, Physiological Function of Bromoperoxidase in the Red Marine Alga, Corallina pilulifera: Production of Bromoform as an Allelochemical and the Simultaneous Elimination of Hydrogen Peroxidase, Phytochemistry, 58, 683-692 (2001).
  4. N. Ohsawa, M. Tsujita, S. Morikawa and N. Itoh, Purification and Characterization of a Monohalomethane-producing Enzyme S-Adenosyl-L-methionine: Halide Ion Methyltransferase from a Marine Microalga, Pavlova pinguis, Biosci. Biotechnol. Biochem., 65, 2397-2404 (2001).
  5. T. Dairi, Y. Hamano, T. Kuzuyama, N. Itoh, K. Furihata and H. Seto, Eubacterial Diterpene Cyclase Genes Essential for Production of Isoprenoid Antibiotic Terpentecin, J. Bacteriol., 183, No. 20, 6085-6094 (2001).

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【2002年】

  1. T. Kawanami, M. Miyakoshi, T. Dairi and N. Itoh, Reaction Mechanism of the Co2+-Activated Multifunctional Bromoperoxidase-Esterase from Pseudomonas putida IF-3, Arch. Biochem. Biophys., 398, 94-100 (2002).
  2. N. Itoh, M. Matuda, M. Mabuchi, T. Dairi and J. Wang, Chiral Alcohol Production by NADH-dependent Phenylacetaldehyde Reductase Coupled with in situ Regeneration of NADH, Eur. J. Biochem., 269, 2394-2402 (2002).
  3. Y. Hamano, T. Dairi, M. Yamamoto, T. Kuzuyama, N. Itoh, H. Seto, Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain, Biosci. Biotechnol. Biochem., 66, 808-819 (2002).
  4. Y. Hamano, T. Kuzuyama, N. Itoh, K. Furihata, H. Seto, and T. Dairi, Functional Analysis of Eubacterial Diterpene Cyclases Responsible for Biosynthesis of a Diterpene Antibiotic Terpentecin, J. Biol. Chem., 277, 37098-37104 (2002).
  5. 5. T. Kuzuyama, S. Takahashi, T. Dairi, and H. Seto, Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene, J. Antibiot., 55, 919-923 (2002).

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【2003年】

  1. T. Kawasaki, Y. Hamano, T. Kuzuyama, N. Itoh, H. Seto, and T. Dairi, Interconversion of the Product Specificity of Type I Eubacterial Farnesyl Diphosphate Synthase and Geranylgeranyl Diphosphate Synthase through One Amino Acid Substitution, J. Biochem., 133, 83-91 (2003).
  2. T. Eguchi, Y. Dekishima, Y. Hamano, T. Dairi, H. Seto, and K. Kakinuma, Application of New Biosynthetic Approach Featuring Pathway Switching, Deuterium Hyperlabeling and 1H NMR Spectroscopy. The Reaction Mechanism of Novel Streptomyces Diterpene Cyclase., in press, J. Org. Chem. (2003).
  3. N. Itoh, T. Kawanami, C. Nitta, N. Iwata, S. Usami, Y. Abe, and Y. Koide, Characterization of pNI10 Plasmid in Pseudomonas and The Construction of an Improved Escherichia and Pseudomonas Shuttle Vector, pNUK73, Appl. Microbiol. Biotechnol., 61, 240-246 (2003).
  4. J. Q. Liu, T. Dairi, N. Itoh, M. Kataoka, and S. Shimizu, A Novel Enzyme, D-3-hydroxyaspartate Aldolase from Paracoccus dentrificans IFO 13301: Purification, Caracterization, and Gene Cloning. Appl. Microbiol. Biotechnol., 62, 53-60 (2003).

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【2004年】

  1. N. Itoh, H. Asako, K. Banno, Y. Makino, R. Wakita, M. Shimizu, Purification and characterization of NADPH-dependent aldo-keto reductase specific for β-keto esters from Penicillium citrinum, Appl. Microbiol. Biotechnol., 66, 53-62 (2004).
  2. T. Kawasaki, T. Kuzuyama, Y. Kuwamori, N. Matsuura, N. Itoh, K. Furihata, H. Seto, T. Dairi, Presence of copslyl diphosphate synthase gene in an antinomycete possessing the MV pathways, J. Antibiotics, 57, 739-747 (2004).
  3. T. Kuzuyama, T. Dairi, H. Yamashita, Y. Shoji, and H. Seto, Heterologous mevalonate production in Streptomyces lividans TK23, Biosci. Biotech. Biochem., 68, 931-934 (2004).
  4. T. Nakano, K. Miyake, H. Endo, T. Dairi, T. Mizukami, and R. Katsumata, Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens. Biosci. Biotech. Biochem., 68, 1345-1352 (2004).

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【2005年】

  1. H. Asako, R. Wakita, K. Matsumura, M. Shimizu, J. Sakai, N. Itoh, Purification and cDNA cloning of NADPH-dependent aldoketoreductase, involved in asymmetric reduction of methyl 4-bromo-3-oxobutyrate, from Penicillium citrinum IFO463, Appl. Environ. Microbiol., 71, 1101-1104 (2005).
  2. K. Inoue, Y. Makino, N. Itoh, Production of (R)-chiral alcohols by a hydrogen-transfer bioreduction with NADH-dependent Leifsonia alcohol dehydrogenase (LSADH), Tetrahedron: Asymmetry, 16, 2539-2549 (2005).
  3. K. Inoue, Y. Makino, N. Itoh, Purification and characterization of a novel alcohol dehydrogenase from Leifsonia sp. strain S749: a promising biocatalyst for an asymmetric hydrogen transfer bioreduction, Appl. Environ. Microbiol., 71, 3633-3641 (2005).
  4. Y. Makino, K. Inoue, T. Dairi, N. Itoh, Engineering of phenylacetaldehyde reductase for efficient substrate conversion in concentrated 2-propanol, Appl. Environ. Microbiol., 71, 4713-4720 (2005).
  5. C. Nakano, T. Okamura, T. Sato, T. Dairi, and T. Hoshino, Mycobacterium tuberculosis H37Rv 3377c encodes the diterpene cyclase for producing halimane skeleton. Chem. Commun., Issue 8: 1016-1018 (2005).
  6. K. J. Puan, H. Wang, T. Dairi, T. Kuzuyama, and C. T. Morita, fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. FEBS Lett. 579, 3802-3806, (200).
  7. T. Dairi, Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes, J. Antibiot. 58, 227-243 (2005).

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【2006年】

  1. K. Inoue, Y. Makino, T. Dairi, N. Itoh, Gene cloning and expression of Leifsonia alcohol dehydrogenased (LSADH) involved in asymmetric hydrogen-transfer bioreduction to produce (R)-form chiral alcohols. Biosci. Biotechnol. Biochem., 70, 418-426 (2006).
  2. T. Kawasaki, Y. Hayashi, T. Kuzuyama, K. Furihata, N. Itoh, H. Seto, and T. Dairi, Biosynthesis of a natural polyketide-isoprenoid hybrid compound furaquinocin A: Identification and heterologous expression of the gene cluster. J. Bacteriol., 188, 1236-1244 (2006).
  3. Z.Kamenarska, M.Hiraoka, N.Itoh, Preliminary study on the bromoperoxidase activity of some macroalgae from Japan, Compt. Rend. Acad. Bulg. Sci., 59, 71-74(2006).

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【2007年】

  1. N. Itoh, M. Nakamura, K. Inoue, Y. Makino, Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor: promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction, Appl. Microbiol. Biotechnol., 75, 1249-1256 (2007).
  2. Y. Makino, T. Dairi, N. Itoh, Engineering the phenylacetaldehyde reductase mutant for improved substrate conversion in the presence of concentrated 2-propanol, Appl. Microbiol. Biotechnol., 77, 833-843 (2007).
  3. Z. Kamenarska, T. Taniguchi, N. Ohsawa, M. Hiraoka, N. Itoh, A vanadium-dependent bromoperoxidase in the marine red alga Kappaphycus alvarezii (Doty) Doty displays clear substrate specificity, Phytochemistry, 68, 1358-1366 (2007).
  4. N. Itoh, Y. Katsube, K. Yamamoto, N. Nakajima, K. Yoshida, Laccase-catalyzed conversion of green tea catechins in the presence of gallic acid to epitheaflagallin and epitheaflagallin 3-O-gallate, Tetrahedron, 63, 9488-9492 (2007).
  5. Y. Hayashi, H. Onaka, N. Itoh, H. Seto, T. Dairi, Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid, Biosci. Biotech. Biochem., 71, No.12 (2007).
  6. T. Toyomasu, M. Tsukahara, A. Kaneko, R. Niida, W. Mitsuhashi, T. Dairi, N. Kato,T. Sassa, Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi, Proc. Natl. Acad. Sci. U S A, 104, 3084-3088 (2007).
  7. K. Motohashi, R. Ueno, M. Sue, K. Furihata, T. Matsumoto, T. Dairi, S. Omura, H. Seto, Studies on terpenoids produced by actinomycetes: oxaloterpins A, B, C, D, and E, diterpenes from Streptomyces sp. KO-3988, J. Nat. Prod. 70, 712-1717 (2007).

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【2008年】

  1. H. Asako, M. Shimizu, N. Itoh, Engineering of NADPH-dependent aldo-keto reductase from Penicillium citrinum by directed evolution to improve thermostability and enantioselectivity, Appl. Microbiol. Biotechnol., 80, 803-812, (2008).
  2. T. Hiratsuka, K. Furihata, J. Ishikawa, H. Yamashita, N. Itoh, T. Dairi, An alternativemenaquinone biosynthetic pathway operating in microorganisms, Science, 19, 1670-1673 (2008).
  3. Y. Makino, N. Itoh, A knowledge-based structure-discriminating function that requires only main-chain atom coorcinates, BMC Structural Biology, 8, 46 (2008).
  4. Y. Hayashi, N. Matsuura, H. Toshima, N. Itoh, J. Ishikawa, Y. Mikami, T. Dairi, Cloning of the gene cluster responsible for the biosynthesis of brasilicardin A, a unique diterpenoide. J. Antibiot., 61, 164-174 (2008).
  5. H. Seto, Y. Jinnai, T. Hiratsuka, M. Fukawa, K. Furihata, N. Itoh, T. Dairi, Studies on a new biosynthetic pathway for menaquinone, J. Am. Chem. Soc., 130, 5614-5615, (2008).

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【2009年】

  1. N. Itoh, H. Toda, M. Matsuda, T. Negishi, T. Taniguchi, N. Ohsawa, Involvement of S-adenosylmethionine-dependent halide/thiol methyltransferase (HTMT) in methyl halide emissions from agricultural plants: isolation and characterization of an HTMT-coding gene from Raphanus sativus (daikon radish), BMC Plant Biology, 9:116, (2009).
  2. H. Asako, M. Shimizu, N. Itoh, Biocatalytic production of (S)-4-bromo-3-hydroxybutyrate and structurally related chemicals and their application, Appl. Microbiol. Biotechnol., 84, 397-405, 2009.
  3. N. Itoh, Y. Katsube, Biocatalytic conversion of green tea catechins to epitheaflagallin, epitheaflagallin, 3-O-gallate, and theaflavins: production of promising functional foods, In Handbook of Green Tea and Health Research (H. McKinley and M. Jamieson, eds.), pp. 419-427, Nova Science Publishers, Inc., (2009).
  4. T. Hiratsuka, N. Itoh, H. Seto, T. Dairi, Enzymatic properties of futalosine hydrolase, an enzyme essential to a new identified menaquinone biosynthetic pathway, Biosci. Biotechnol. Biochem., 73, 1137-1141 (2009).
  5. A. Minami, N. Tajima, Y. Higuchi, T. Toyomasu, T. Sassa, N. Kato, T. Dairi, Identification and Functional Analysis of Brassicicene C Biosynthetic Gene Cluster in Alternaria brassicicola., Bioorg. Med. Chem. Lett., 19, 870-874 (2009).
  6. C. Nakano, T. Hoshino, T. Sato, T. Toyomasu, T. Dairi, T. Sassa, Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates, Tetrahedron Lett., 51, 125-128 (2009).
  7. T. Dairi, An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains, J. Antibiot., 62, 347-352 (2009).

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【2010年】

  1. J. Kurokawa, M. Asano, S. Nomoto, Y. Makino, N. Itoh, Gene cloning and characterization of dihydrolipoamide dehydrogenase from Microbacterium luteolum: A useful enzymatic regeneration system of NAD+ from NADH, J. Biosci. Bioeng., 109, 218-223, (2010).
  2. H. Asako, M. Shimizu, Y. Makino, N. Itoh, Biocatalytic reduction system for the production of chiral methyl (R)/(S)-4-bromo-3-hydroxybutyrate, Tetrahedron Lett., 51, 2664-2666 (2010).

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【2011年】

  1. H. Toda, N. Itoh, Isolation and characterization of a gene encoding a S-adenosyl-L-methionine-dependent halide/thiol methyltransferase (HTMT) from the marine diatom Phaeodactylum tricornutum: Biogenic mechanism of CH3I emission in oceans, Phytochemistry, 72, 337-343, (2011).
  2. C. Arakawa, M. Kuratsu, K. Furihata, T. Hiratsuka, N. Itoh, H. Seto, T. Dairi, Diversity of the early step of the futalosine pathway, Antimicrob. Agents Chemother., 55, 913-915 (2011).
  3. R. Tanaka, T. Kunisada, K. Kushida, K. Yamada, S. Ikeda, M. Noike, Y. Ono, N. Itoh, H. Takami, H. Seto, T. Dairi, Branched fatty acids inhibit the biosynthesis of menaquinone in Helicobacter pylori, J. Antibiotics, 64, 151-153 (2011).

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【2012年】

  1. N. Itoh, K. Isotani, M. Nakamura, K. Inoue, Y. Isogai, Y. Makino, Efficient synthesis of optically pure alcohols by asymmetric hydrogen-transfer biocatalysis: application of engineered enzymes in a 2-propanol-water medium, Appl. Microbiol. Biotechnol., 93, 1075-1085 (2012).
  2. K. Isotani, J. Kurokawa, N. Itoh, Production of (R)-3-quinuclidiol by E. coli biocatalysts possessing NADH-dependent 3-quinuclidinone reductase (QNR or bacC) from Microbacterium luteolum and Leifsonia alcohol dehydrogenase (LSADH), Int. J. Mol. Sci., 13, 13542-13553 (2012).
  3. H. Toda, N. Itoh, Isolation and characterization of styrene metabolic genes from styrene-assimilating soil bacteria Rhodococcus sp. ST-5 and ST-10, J. Biosci. Bioeng., 113, 12-19 (2012).
  4. H. Toda, R. Imae, T. Komio, N. Itoh, Expression and characterization of styrene monooxygenases of Rhodococcus sp. ST-5 and ST-10 for synthesizing enantiopure (S)-epoxides, Appl. Microbiol. Biotechnol., 96, 407-418 (2012)
  5. H. Toda, R. Imae, N. Itoh, Efficient biocatalysis for the production of enantiopure (S)-epoxides using styrene monooxygenase (SMO) and Leifsonia alcohol dehydrogenase (LSADH) system, Tetrahedron: Asymmetry, 23, 1542-1549 (2013)
  6. S. Yamamoto, W. Gunji, H. Suzuki, H. Toda, M. Suda, T. Jojima, M. Inui, H. Yukawa, Overexpression of glycolytic genes enhances Corynebacterium glutamicum glucose metabolism and alanine production under oxygen-deprived conditions. Appl. Environ. Microbiol., 78, 4447-4457 (2012).

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【2013年】

  1. K. Isotani, J. Kurokawa, F. Suzuki, S. Nomoto, T. Negishi, M. Matsuda, N. Itoh, Gene cloning and characterization of two NADH-dependent 3-quinuclidinone reductases from Microbacterium luteolum JCM 9174, Appl. Environ. Microbiol., 79, 1378-1384 (2013).
  2. Y. Makino, N. Itoh, Development of an improved phenylacetaldehyde reductase mutant by an efficient selection procedure, Appl. Microbiol. Biotechnol., 79, 1378-1384 (2013).
  3. N. Itoh, Y. Makino, Protein engineering: development of novel enzymes for the improved reduction of C=O double bonds, In: E. Brenna (ed), Synthetic methods for biologically active molecules, pp. 139-185, Wiley-VCH, Germany (2013).

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【2014年】

  1. N. Itoh, S. Kariya, J. Kurokawa, Efficient PCR-based amplification of diverse alcohol dehydrogenase genes from metagenomes for improving biocatalysis: Screening of gene-specific amplicons from metagenomes, Appl. Environ. Microbiol., 80, 6280-6289 (2014)./Erratum 2016,82, 61
  2. N. Itoh, Use of anti-Prelog stereospecific alcohol dehydrogenase from Leifsonia and Pseudomonas for producing chiral alcohols, Appl. Microbiol. Biotechnol., 98, 3889-3904 (2014).
  3. N. Itoh, K. Isotani, Y. Makino, M. Kato, K. Kitayama, T. Ishimota, PCR-based amplification and heterologous expression of Pseudomonas alcohol dehydrogenase genes from the soil metagenomes for biocatalysis, Enzyme Microb. Technol., 55, 140-150 (2014).
  4. Y. Yokouchi, A. Ooki, S. Hahimoto, N. Itoh, A study on the production and emission of marin-derived volatile halocarbons, In: M. Uematsu et al. (ed), Western Pacific Air-Sea Interaction Study, pp. 1-25, TERRAPUB (2014).
  5. H. Toda, R. Imae, N. Itoh, Bioproduction of chiral epoxyalkanes using styrene monooxygensae from Rhodococcus sp. strain ST-10 (RhSMO), Adv. Synth. Catal., 356, 3443-3450 (2014).

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【2015年】

  1. H. Toda, T. Ohuchi, R. Imae, N. Itoh, Microbial production of aliphatic (S)-epoxyalkanes by using Rhodococcus sp. strain ST-10 styrene monooxygenase expressed in organic-solvent-tolerant Kocuria rhizophila DC2201, Appl. Environ. Microbiol., 81:1919-1925 (2015).
  2. C. E. Paul, D. Tischler, A. Riedel, T. Heine, N. Itoh, F. Hollmann, Nonenzymatic regeneration of styrene monooxygenase for catalysis, ACS Catal., 5:2961-2965 (2015).

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【2016年】

  1. N. Itoh, S. Takagi, A. Miki, J. Kurokawa, Characterization and cloning of laccase gene from Hericium coralloides NBRC 7716 suitable for production of epitheaflagallin 3-O-gallate, Enzym. Microb. Technol., 82:125-132 (2016).
  2. N. Itoh, M. Kazama, N. Takeuchi, K. Isotani, J. Kurokawa, Gene-specific amplicons from metagenomes as an alternative to directed evolution for enzyme screening: a case study using phenylacetaldehyde reductases, FEBS Open Bio., 6:566-575 (2016).
  3. N. Itoh, C. Iwata, H. Toda, Molecular cloning and characterization of a flavonoid-O-methyltransferase with broad substrate specificity and regioselectivity from Citrus depressa, BMC Plant Biology, 16: 180 (2016).

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【2017年】

  1. H. Toda, T. Koyanagi, T. Enomoto, N. Itoh, Characterization of two cryptic plasmids from Kocuria palustris IPUFS-1 and construction of novel Escherichia coli-Kocuria shuttle vector for biocatalysis. J. Biosci. Bioeng., 124:255-264 (2017).
  2. H. Toda, N. Itoh, Development of a novel E. coli-Kocuria shuttle vector using the cryptic pKPAL3 plasmid from K. palustris IPUFS-1 and its utilization in producing enantiopure (S)-styrene oxide. Front. Microbiol., article2313 (2017).
  3. N. Itoh, J. Kurokawa, Y. Isogai, M. Ogasawara, T. Matsunaga, T. Okubo, Functional characterization of epitheaflagallin 3-O-gallate generated in laccase-treated green tea extracts in the presence of gallic acid. J. Agric. Food Chem., 65:10473-10481 (2017).
  4. N. Itoh, J. Kurokawa, H. Toda, K. Konishi, Identification and characterization of a novel (-)-vibo-quercitol 1-dehydrogenase from Burkholderia terrae suitable for production of (-)-vibo-quercitol from 2-deoxy-scyllo-inosose. Appl. Microbiol. Biotechnol.,101: 7545-7555 (2017).
  5. N. Itoh, Metagenomics for improved biocatalysis, In Future Directions in Biocatalysis 2nd ed. (ed. by T. Matsuda) pp.375-383, Elsevier (2017).

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【2018年】

  1. N. Itoh, Biosynthesis and production of quercitols and their application in the production of pharmaceuticals:current status and prospects, Appl. Microbiol. Biotechnol.,102: 4641-4651(2018).

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博士論文　[Ph.D Theses]

  • (N. Ohsawa)
    "Studies on the halogenating enzymes from marine algae and their physiological function" (2001)
  • (Y. Hamano)
    "Studies on the biosynthesis of terpenoids produced by streptomyces" (2002)
  • (T. Kawanami)
    "Studies on the multifunctional bromoperxidase from Pseudomonas putida IF-3 and its application" (2003)
  • (T. Kawasaki)
    "Studies on the biosynthetic genes and enzymes responsible for the formation of basic skeletons of isoprenoids produced by actinomycetes"(2005)
  • (K. Inoue)
    "Studies on the production of chiral alcohols using alcohol dehydrogenase (LSADH) from Leifsonia sp. S749" (2006)
  • (Y. Hayashi)
    "Studies on the key enzymes leading to the diversity of isoprenoids found in actinomycetes" (2007)
  • (T. Hiratsuka)
    "An alternative menaquinone biosynthetic pathway operating in microorganisms" (2009)
  • (H. Asako)
    "Studies on the production of chiral methyl (S)-4-bromo-3-hydroxybutyrate using a novel NADPH-dependent beta-keto ester reductase from Penicilium citrinum" (2011)
  • (K. Isotani)
    "Studies on the efficient biocatalysis for producing optically pure alcohols including (R)-(-)-quinuclidinol" (2013)

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著書・総説

  1. 大利　徹
    ユニークな反応を触媒する抗生物質生合成酵素・遺伝子群の解析、日本農芸化学会誌、74巻、No.9、975-983 (2000).
  2. 伊藤　伸哉、 大沢　登
    生物界由来の揮発性ハロゲン化合物の生成機構と循環、特定領域研究「対流圏グローバルダイナミクス」News Letters, No.6, 65-70 (2001).
  3. 伊藤　伸哉、 谷口　友一、大沢　登
    植物起源のモノハロメタンとその生成機構、富山県立大学紀要、12、54-60 (2002).
  4. 濱野　吉十、 大利　徹、 山本　正浩、 川崎　崇、 金田　一秀、 葛山　智久、伊藤　伸哉、 瀬戸　治男
    テルペノイド抗生物質生産放線菌からのメバロン酸経路遺伝子クラスターのクローニング、日本農芸化学会誌、 76 (11)、 1092-1093 (2002).
  5. 大利　徹、 濱野　吉十、 伊藤　伸哉、 葛山　智久、 降旗　一夫、 瀬戸　治男
    原核生物に見いだされたジテルペンサイクラーゼの機能解析、日本農芸化学会誌、76 (12)、1191-1194 (2002).
  6. 大利　徹
    放線菌の多様なイソプレノイド生合成遺伝子、バイオサイエンスとインダストリー　64, 433-438 (2006).
  7. 伊藤　伸哉、牧野　祥嗣
    「有機溶媒耐性酵素」pp.32-41, 今中忠行 監修、酵素開発・利用の最新技術　シーエムシー出版 （2006.12).
  8. 牧野　祥嗣、伊藤　伸哉
    蛋白質の二次構造休止点の推定、富山県立大学紀要、17、78-83 (2007).
  9. 伊藤　伸哉
    水素移動型バイオ不斉還元による光学活性アルコールの効率的生産　月刊ファインケミカル37 (No.1), 44-48 (2008).
  10. 松永　孝之、小笠原　勝、伊藤　伸哉、勝部　祐至、山本　恵一、吉田　賢三郎
    紅茶ポリフェノールのグリケーション及び消化酵素の阻害活性について　富山県薬事研究年報vol.35, 15-20, 2008.
  11. 小笠原　勝、松永　孝之、伊藤　伸哉、勝部　祐至、山本　惠一
    歯周病に対する紅茶ポリフェノールの有用性の評価　　富山県薬事研究年報vol.35, 21-28, 2008.
  12. 伊藤　伸哉
    有機溶媒耐性酵素の開発と医薬品中間体製造　月刊バイオインダストリー　26 (No.4), 34-44 (2009).
  13. 勝部　祐至、伊藤　伸哉
    「ラッカーゼによる緑茶カテキン類の変換」　井上　國世監修 産業酵素の応用技術と最新動向　pp.93-100シーエムシー出版 (2009).
  14. 伊藤　伸哉
    酵素法によるキラルアルコールの生産②　酵素利用技術大系　pp.423-429, エヌ・ティー・エス出版　（2010）.
  15. 伊藤　伸哉
    進化分子工学的手法による極性有機溶媒耐性PARの創製と生産性の向上　伏見譲　監修　進化分子工学、pp.307-317, エヌ・ティー・エス出版 (2013).
  16. 戸田　弘、伊藤　伸哉
    進化分子工学を利用した光学活性エポキシ化合物生産プロセスの開発 伏見譲　監修　進化分子工学、pp.297-305, エヌ・ティー・エス出版 (2013).
  17. 戸田　弘、伊藤　伸哉
    スチレンモノオキシゲナーゼを利用した光学活性エポキシアルカン化合物の生産　バイオサイエンスとインダストリー, vol.2, pp.121-125 (2015)
  18. 伊藤伸哉
    メタゲノムからの産業用酵素の探索技術：S-GAM法による酵素遺伝子の効率的単離とその応用　化学と生物, vol. 53(10): 651-653, (2015)

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