THERAPEUTICALLY ACTIVE NANOMATERIALS FOR THE TREATMENT OF EYE DISEASES
are Murakami Lab’s main target. Such nanosmaterials are designed and created on the basis of a natural nanomaterial in our body, high-density lipoprotein (HDL). HDL is a ~10 nm material that consists mainly of a lipid-binding protein and a phospholipid membrane. HDL displays various biological activities during blood circulation, including cholesterol efflux capacity, anti-inflammatory activity, anti-oxidative activity. We are developing the nanomaterials with these increased activities as well as unnatural functions as eye drops.
News & Topics
A research proposal based on the joint research with Kyoto Univ Hospital was accepted by Kyoto University Open Innovation Institute.
Congratulation on your graduations. Good luck to Rumina, Ryo, and Rin!
08/02/2023EventGraduation Thesis Presentation
Tsukasa Ohashi, Haruka KURITA, and Rin ONAGA made a poster presentation. Well done! Their long effort for preparing their presentation should be appreciated.
Ryo KAWAKAMI (M2) and Shiori SHIBUKAWA (M1) made poster presentations at the 45 th Annual Meeting of the Molecular Biology Society of Japan.
"Neovasculature-Targeted Lipoprotein Mutant Eye Drops for the Treatment of Wet Age-Related Macular Degeneration in Mice" (Ryo)
"Corneal Epithelial Cell Affinity and Posterior Eye Drug Delivery Ability of Lipoprotein Variants" (Shiori)
26/10/2022EventNew Lab Members and Welcome Party
Hayato TAKAGIi (B3), Yumemi TAJIMA (B3), and Reina NAKANISHI (B3) have joined and started their graduation research, and a lunch party was held for them in a park near the campus.
Tsukasa (B4) made an oral presentation at the Annual Meeting of the Hokuriku Branch of the Society of Polymer Science, Japan .
"Development of intraretinal DDS for treatment of early-stage age-related macular degeneration"
The review article entitled "High-density lipoprotein as a therapeutic target of age-related macular degeneration" was published in BIO Clinica (Japanese). This article summarizes how high-density lipoprotein's biological activities counteract the pathogenesis of age-related macular degeneration in human and experimental animals.
Prof. Murakami gave an invited talk at the 241th ECS meeting (digital).
"Donor-Acceptor-Linked Molecules for Controlling the Membrane Potential of Living Cells"
Congratulation on your graduations. Good luck to Yui!
09/02/2022EventGraduation Thesis Presentation
Shiori SHIBUKAWA, Yui TSUKIO, and Yuu Mizukami made an oral presentation online. Well done! Their long effort for preparing their presentation should be appreciated.
Rumina SHIMA made a poster presentation at the Materials Research Meeting 2021 (MRM2021) in Yokohama.
"Blood Circulation Property of High-Density Lipoprotein in Zebrafish"
A tea party was held for the new lab members after a photo session. The party was organized by the fourth-year students. Thanks!
01/10/2021EventNew Lab Members
Tsukasa OHASHI (B3), Rin ONAGA (B3), and Haruka KURITA (B3) have joined and started their graduation research.
Prof. Murakami gave an invited talk at ICFPE2021 (online).
"Photo-Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecule"
Ryosuke FUKUDA and Rumina SHIMA made an online poster presentation at the Toyama Basel Meeting 2021.
"Potential of Engineered Lipoprotein Eye Drops for the Treatment of Age-Related Macular Degeneration (Fukuda)"
"Comparative Analysis of the Pharmacokinetic Properties of High-Density Lipoprotein between Zebrafish embyos and mice (Shima)"
Prof. Murakami gave an invited talk at the Annual Meeting on Photochemistry 2021 (online).
01/08/2021EventNew Lab Member
Ryosuke FUKUDA has joined as a KAKENHI "Dynamic Excition" postdoc.
Rumina SHIMA and Ryo KAWAKAMI made an online poster presentation at the 37th Annual Meeting of the Japan Society of Drug Delivery System.
Prof. Murakami gave an invited talk at the 239th ECS meeting (online).
"Optical Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecules"
Tomohiro NOBEYAMA and Ryosuke FUKUDA were selected as JSPS postdoc (DC2).
Our application regarding lipoprotein mutant eye drops for the treatment of posterior eye diseases has filed in Japan (P6818264).
The application for Grant-in-Aid for Transformative Research Areas, “Dynamic Exciton” (Project leader, Prof. Hiroshi Imahori of Kyoto Univ.) was accepted. Prof.Murakami joins as one of the PIs in this project. His research title is “Optical control of the plasma membrane functions by using dynamic exciton.
The book that Tomohiro and Prof.Murakami were involved in was released. What they write was Chapter 24, "Phase Separation of Lipid Membranes and Their Future." It was Tomohiro's first time writing a book.
While maintaining social distance and protecting alcohol disinfection and mask, we held a welcome lunch party for Nargis(Postdoc) and Yui(B3) and Yu(B3) and Shiori(B3).
29/09/2020EventPhD Conferment Ceremony
The ceremony of Ph.D. degree conferment for Ryosuke and Tomohiro was held in the campus. Ryosuke and Tomohiro, congrats!
The original article regarding the optical control of membrane potential with a donor-acceptor-linked molecule was accepted for the publication in Cell. Physiol. Biochem. This work is based on the joint research with Dr. Tomohiro NUMATA (Fukuoka Univ.).
The original article of Tomohiro was accepted for the publication in Langmuir, which is already published on line. Congrats, Tomohiro!
Department of Pharmaceutical Engineering, Faculty of Engineering Toyama Prefectural University
Tatsuya Murakami Lab.
5180 Kurokawa, Imizu City, Toyama, 939-0398, Japan
Email : murakami(at))pu-toyama.ac.jp
Phone: 0766-56-7500 (within Japan),
Fax:0766-56-2498 (within Japan),