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News & Topics

• 17/02/2024
  Work
  Invited Review Article
  Haruka's paper has been accepted for publication in Nanomedicine (Lond). This paper briefly explores the potential of engineered HDL eye drops for the treatment of age-related macular degeneration. The title is
  "The distinct properties of high-density lipoprotein nanoparticles as ocular drug delivery vehices".
• 17/02/2024
  Event
  Defense
  Koji TAKATA made his oral presentation on his doctoral dissrtation. The title was
  "Lipid Nanoparticle Fabrication and Cell Separation Using Injection-Molded Microfluidic Devices".
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• 10/02/2024
  Event
  Graduation Thesis Presentation
  Kiseki KOBAYASHI, Kohei KOYAMA, and Machiho NISHIDA made their poster presentations. Well done! Their long effort for preparing their presentation should be appreciated.
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• 12/12/2024
  Work
  Invited Presentation
  Prof. Murakami gave an invited talk at International Symposium on Exponential Biomedical DX 2024 (eMEDX-24, JAIST), and the title was
  "Drug delivery system for photodynamic therapy of eye diseases with engineered lipoprotein".
  
  Haruka KURITA and Reina NAKANISHI made theeir poster presentations at the same symposium, and their title were
  "Preparation of thermosensitive lipid nanoparticles using apolipoprotein A-I-derived peptide and evaluation of their biological activities Haruka)"
  "Development of endothelial cell-adhesive high-density lipoprotein nanoparticles for sepsis (Reina)"
  
• 12/12/2024
  Work
  Invited Presentation
  Prof. Murakami gave an invited talk at the 12th Singapore International Chemistry Conference (SICC-12, Singapore), and the title was
  "Photodynamic therapy for neovascular age-related macular degeneration using verteporfin-loaded lipoprotein nanoparticles".
• 28/11/2024
  Work
  Meeting
  Haruka KURITA (M2) made her posterl presentation at the 47nd Annual Meeting of the Molecular Biology Society of Japan in Hakata.
  "Preparation and biological activity evaluation of thermoresponsive lipid nanoparticles using an apolipoprotein A-I-derived peptide"
• 07/11/2024
  Work
  Meeting
  Reina NAKANISHI (M1) made her posterl presentation at the 97nd Annual Meeting of the Japanese Biochemical Society in Yokohama.
  "Development of photodynamic therapy for age-related macular degeneration focusing on the function of high-density lipoprotein"
• 01/10/2024
  Work
  Original Article
  Hayato's paper has been accepted for publication in Beilstein Journal of Organic Chemistry. This is the result of joint research among ETH Zürich, Kyoto University, and TPU, and is available online. We have developed a method that simultaneously enables the control of the intramembrane location of a fullerene derivative, a model of photoinduced charge-separation molecules used in Grant-in-Aid for Innovative Areas research, and the suppression of reactive oxygen species formation. The key to this method is the utilization of pyrenebutyric acid, which is capable of intra-membrane π–π interactions with fullerene derivatives.
• 
• 01/10/2024
  News
  Research Fund
  The application for the Kansai Startup Academia Coalition (KSAC) GAP Fund for Overseas Deployment was accepted. Prof. Murakami joins as the co-PI in this project (PI, Dr. Kenji Suda at KUHP). The research title is “Development of Neovasculature-Targeted Drug Delivery Systems".
• 06/08/2024
  Event
  Welcome Party
  Three 6^th-year students from the Department of Pharmacy, Chiang Mai University (CMU), joined the laboratory as special research students of TPU, based on the Student Exchange Agreement between CMU and TPU. Welcome, Best-san, Mind-san, and Nice-san! They will conduct experimental research for two months, according to the internship program in CMU.
• 
• 01/07/2024
  Work
  Meeting Presentation
  Haruka KURITA (M2) and Reina NAKANISHI (M1) made oral presentations at the 42nd Annual Meeting of the Japanese Biochemical Society Hokuriku Branch in Kanazawa, and Haruka won the best student presentation award.
  "Preparation of thermosensitive and anti-inflammatory lipid nanoparticles using apolipoprotein A-I-derived peptide" (Haruka)
  "Development of endothelial cell-adhesive high-density lipoprotein nanoparticles" (Reina)
• 03/06/2024
  Work
  Patent
  A substance patent has been granted for our eye drop for the treatment of neovascular age-related macular degeneration, which is a neovasculature-targeted and corneal absorption-enhancing HDL mimetic reported in Adv. Therap. (2023).
• 28/05/2024
  Work
  Original Article
  Koji's paper regarding very high-yield microfluidic preparation of high-density lipoprotein (HDL) mimtics was accepted for the publication in Lab on a Chip. We found that turbulent mixing was likely to occur when three evenly spaced inlets were arranged on one side of a simple cuboidal microfluidic chip and an ethanolic lipid solution was injected from the central inlet and an aqueous protein solution from the left and right inlets in a symmetrical manner. As a result, reconstituted HDL nanoparticles were obtained with a protein-equivalent yield of >90%, which is probably the highest yield in the world.
• 26/05/2024
  Work
  Invited Presentation
  Prof. Murakami gave an invited talk at 245th ECS Meeting (San Francisco), and the title was.
  "Drug Delivery System of Photoresponsive Donor-Acceptor-Linked Molecules to Mouse Retina".
• 25/04/2024
  Event
  Welcome Tea Party
  Dr. Sawangrat Kasirawat (Chiang Mai Univ., Thailand), who worked as a postdoc in TPU in 2010, joined the lab again. The purpose of his stay is to do our joint research about the medical application of HDL mimetics he designed.
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• 16/03/2024
  Event
  Commencement Ceremony
  Congratulation on your degree. Good luck to Shiori, Yu, and Yumemi!
  
• 09/02/2024
  Event
  Graduation Thesis Presentation
  Hayato TAKAGI, Yumemi Tajima, and Reina NAKANISHI made a poster presentation. Well done! Their long effort for preparing their presentation should be appreciated.
• 
• 29/12/2023
  Work
  Original Article
  The original article regarding drug loading into engineered high-density lipoprotein (HDL) nanoparticles was accepted for the publication in ACS Appl. Bio Mater.. Drug-loaded HDL nanoparticles were freeze-dryable and colloidally more stable than drug-loaded liposomes in an artificial tear solution.
• 14, 16/11/2023
  Work
  Invited Lectures in Thailand
  Prof. Murakami gave invited lectures at the Departments of Pharmacy and Science in Chiang Mai University and at the department of Pharmacy in Mahidol University.
  "High-Density Lipoprotein Engineering for Eye Drop Treatment of Age-Related Macular Degeneration"
• 
• 18/10/2023
  Work
  Original Article
  The original article regarding comparative analysis of cell binding/internalization of variously engineered high-density lipoprotein nanoparticles in HeLa cells and BY-2 protoplasts was accepted for the publication in Genes Cells (sharable link). The eye drops were genetically engineered high-density lipoprotein (HDL) nanoparticles with corneal/conjunctival absorption-enhancing and neovasculature-targeting abilities. The HDL's biological activities of the nanoparticles were also analyzed.
• 17/10/2023
  Event
  New Lab Members and Welcome Party
  Kiseki KOBAYASHI (B3), Kohei KOYAMA (B3), and Machiho NISHIDA (B3) have joined and started their graduation research, and a lunch party was held in the campus.
• 
• 29/08/2023
  Work
  Research Grant
  A research proposal entitled "Biomaterials for Prevention/Treatment of Eye Flail" by Hisaharu Ame Research Grant.
• 29/08/2023
  Work
  Meeting Presentation
  Prof. Murakami gave an invited talk at 7th Toyama-Basel Joint Symposium.
  "High-Density Lipoprotein Engineering for Eye Drop Treatment of Age-Related Macular Degeneration"
• 08/08/2023
  Work
  Original Article
  The original article regarding synthesis of butterfly-shaped gold nanoparticles and optical control of liquid-liquid phase transition with them was accepted for the publication in Small.
• 03/08/2023
  Work
  Original Article
  The original article regarding developmeent of eye drops for the treatment of age-related macular degeneration was accepted for the publication in Adv. Therap. (open access). The eye drops were genetically engineered high-density lipoprotein (HDL) nanoparticles with corneal/conjunctival absorption-enhancing and neovasculature-targeting abilities. The HDL's biological activities of the nanoparticles were also analyzed.
• 01/08/2023
  News
  Collabolation with Zeon Cooperation
  A joint research on microfluidic preparation of ~10 nm lipid nanoparticles has started.
• 24/04/2023
  Work
  Research Grant
  A research proposal based on the joint research with Kyoto Univ Hospital was accepted by Kyoto University Open Innovation Institute.
• 18/03/2023
  Event
  Commencement Ceremony
  Congratulation on your degree. Good luck to Rumina, Ryo, and Rin!
• 
• 08/02/2023
  Event
  Graduation Thesis Presentation
  Tsukasa Ohashi, Haruka KURITA, and Rin ONAGA made a poster presentation. Well done! Their long effort for preparing their presentation should be appreciated.
• 
• 01/12/2022
  Work
  Meeting Presentation
  Ryo KAWAKAMI (M2) and Shiori SHIBUKAWA (M1) made poster presentations at the 45 th Annual Meeting of the Molecular Biology Society of Japan.
  "Neovasculature-Targeted Lipoprotein Mutant Eye Drops for the Treatment of Wet Age-Related Macular Degeneration in Mice" (Ryo)
  "Corneal Epithelial Cell Affinity and Posterior Eye Drug Delivery Ability of Lipoprotein Variants" (Shiori)
• 
• 26/10/2022
  Event
  New Lab Members and Welcome Party
  Hayato TAKAGI (B3), Yumemi TAJIMA (B3), and Reina NAKANISHI (B3) have joined and started their graduation research, and a lunch party was held for them in a park near the campus.
• 
• 19/10/2022
  Work
  Meeting Presentation
  Tsukasa (B4) made an oral presentation at the Annual Meeting of the Hokuriku Branch of the Society of Polymer Science, Japan .
  "Development of intraretinal DDS for treatment of early-stage age-related macular degeneration"
• 12/06/2022
  Work
  Review Article
  The review article entitled "High-density lipoprotein as a therapeutic target of age-related macular degeneration" was published in BIO Clinica (Japanese). This article summarizes how high-density lipoprotein's biological activities counteract the pathogenesis of age-related macular degeneration in human and experimental animals.
• 01/06/2022
  Work
  Meeting Presentation
  Prof. Murakami gave an invited talk at the 241th ECS meeting (digital).
  "Donor-Acceptor-Linked Molecules for Controlling the Membrane Potential of Living Cells"
• 19/03/2022
  Event
  Commencement Ceremony
  Congratulation on your degree. Good luck to Yui!
• 
• 09/02/2022
  Event
  Graduation Thesis Presentation
  Shiori SHIBUKAWA, Yui TSUKIO, and Yuu Mizukami made an oral presentation online. Well done! Their long effort for preparing their presentation should be appreciated.
• 
• 13/12/2021
  Work
  Meeting Presentation
  Rumina SHIMA made a poster presentation at the Materials Research Meeting 2021 (MRM2021) in Yokohama.
  "Blood Circulation Property of High-Density Lipoprotein in Zebrafish"
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• 14/10/2021
  Event
  Welcome Party
  A tea party was held for the new lab members after a photo session. The party was organized by the fourth-year students. Thanks!
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• 01/10/2021
  Event
  New Lab Members
  Tsukasa OHASHI (B3), Rin ONAGA (B3), and Haruka KURITA (B3) have joined and started their graduation research.
• 01/10/2021
  Work
  Meeting Presentation
  Prof. Murakami gave an invited talk at ICFPE2021 (online).
  "Photo-Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecule"
• 15/09/2021
  Work
  Meeting Presentation
  Ryosuke FUKUDA and Rumina SHIMA made an online poster presentation at the Toyama Basel Meeting 2021.
  "Potential of Engineered Lipoprotein Eye Drops for the Treatment of Age-Related Macular Degeneration (Fukuda)"
  "Comparative Analysis of the Pharmacokinetic Properties of High-Density Lipoprotein between Zebrafish embyos and mice (Shima)"
• 14/09/2021
  Work
  Meeting Presentation
  Prof. Murakami gave an invited talk at the Annual Meeting on Photochemistry 2021 (online).
• 01/08/2021
  Event
  New Lab Member
  Ryosuke FUKUDA has joined as a KAKENHI "Dynamic Excition" postdoc.
• 30/07/2021
  Work
  Meeting Presentation
  Rumina SHIMA and Ryo KAWAKAMI made an online poster presentation at the 37th Annual Meeting of the Japan Society of Drug Delivery System.
• 04/06/2021
  Work
  Meeting Presentation
  Prof. Murakami gave an invited talk at the 239th ECS meeting (online).
  "Optical Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecules"
• 01/04/2021
  News
  Research Position
  Tomohiro NOBEYAMA and Ryosuke FUKUDA were selected as JSPS postdoc (DC2).
• 05/01/2021
  Work
  Patent Registration
  Our application regarding lipoprotein mutant eye drops for the treatment of posterior eye diseases has filed in Japan (P6818264).
• 01/12/2020
  News
  Research Grant
  The application for Grant-in-Aid for Transformative Research Areas, “Dynamic Exciton” (Project leader, Prof. Hiroshi Imahori of Kyoto Univ.) was accepted. Prof.Murakami joins as one of the PIs in this project. His research title is “Optical control of the plasma membrane functions by using dynamic exciton.
• 16/11/2020
  Work
  Book Chapter Presentation
  The book that Tomohiro and Prof.Murakami were involved in was released. What they write was Chapter 24, "Phase Separation of Lipid Membranes and Their Future." It was Tomohiro's first time writing a book.
• 07/10/2020
  Event
  Luncheon Party
  While maintaining social distance and protecting alcohol disinfection and mask, we held a welcome lunch party for Nargis(Postdoc) and Yui(B3) and Yu(B3) and Shiori(B3).
• 29/09/2020
  Event
  PhD Conferment Ceremony
  The ceremony of Ph.D. degree conferment for Ryosuke and Tomohiro was held in the campus. Ryosuke and Tomohiro, congrats!
• 19/08/2020
  Work
  Original Article Presentation
  The original article regarding the optical control of membrane potential with a donor-acceptor-linked molecule was accepted for the publication in Cell. Physiol. Biochem. This work is based on the joint research with Dr. Tomohiro NUMATA (Fukuoka Univ.).
• 05/06/2020
  Work
  Original Article Presentation
  The original article of Tomohiro was accepted for the publication in Langmuir, which is already published on line. Congrats, Tomohiro!