Achivement

Original article

2017

  1. Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance.
    Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T.
    J. Endocrinol. 2017 Dec;235(3):179-191., pii: JOE-17-0351.
    https://www.ncbi.nlm.nih.gov/pubmed/28855315
  2. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
    Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K.
    J. Biol. Chem, 2017 Sep 15;292(37):15378-15394.
    https://www.ncbi.nlm.nih.gov/pubmed/28754693
  3. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.
    Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K.
    Nat. Commun. 2017 Aug 18;8(1):286.
    https://www.ncbi.nlm.nih.gov/pubmed/28819169
  4. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.
    Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo B.N, Kita S, O’Donnell E, Osawa T, Takahashi H, Takano KI, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M.
    Sci. Rep. 2017 Jun 20;7(1):3855.
    https://www.ncbi.nlm.nih.gov/pubmed/28634350
  5. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.
    Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K.
    JCI Insight. 2017;2(7):e90721.
    https://www.ncbi.nlm.nih.gov/pubmed/28405615

2016

  1. Fetal lymphoid progenitors become restricted to B-1 fates coincident with IL-7Rα expression.
    Iida R, Shinoda K, Hattori Y, Nagai Y, Takatsu K, Kouro T.
    PLoS ONE. Oct 28; 11(10)：e0165676，2016.
  2. HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance.
    Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
    Diabetes. 65(12)：3649-3659，2016.
  3. Inflammatory responses increase secretion of MD-1 protein.
    Jennings RT, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S.
    Int. Immunol. 28(10)：503-512，2016.
  4. Isoliquiritigenin attenuates an inflammatory paracrine loop between adipocytes and macrophages and adipose tissue fibrosis through inhibition of innate immune responses.
    Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K.
    Sci. Rep. 6：Article number: 23097 (2016) doi: 10.1038/srep23097
  5. Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1.
    Nakamura T, Nishibu A, Yoshida N, Yasoshima M, Anzawa K, Watanabe Y, Nagai Y, Takatsu K, Ogawa K, Mochizuki T.
    Exp. Dermatol. 25(4)：299-304，2016.
  6. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia.
    Takikawa A, Usui I, Fujisaka S, Ikutani M, Senda S, Hattori S, Tsuneyama K, Koshimizu Y, Inoue R, Tanaka-Hayashi A, Nakagawa T, Nagai Y, Takatsu K, Sasaoka T, Mori H, Tobe K.
    Diabetology International. (Published online) DOI 10.1007/s13340-015-0213-3

2015

  1. Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.
    Yamamoto S, Niida S, Azuma E, Yanagibashi T, Muramatsu M, Huang TT, Sagara H, Higaki S, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Hamashima T, Mori H, Matsuda N, Ishii Y, Sasahara M.
    Sci. Rep.5：Article number: 8505 (2015) doi: 10.1038/srep08505
  2. Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice.
    Tamura K, Ikutani M, Yoshida T, Tanaka-Hayashi A, Yanagibashi T, Inoue R, Nagai Y, Adachi Y, Miyawaki T, Takatsu K, Mori H.
    Immunobiology. 220(5)：597-604，2015.
  3. Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells.
    Yanagibashi T, Nagai Y, Watanabe Y, Ikutani M, Hirai Y, Takatsu K.
    Immunol. Lett. 163(1)：22-31，2015.

2014

  1. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.
    Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, Muraguchi A, Takatsu K.
    J. Leukoc. Biol. 96(6)：1087-1100，2014.
  2. Deficiency of nicotinamide mononucleotide adenyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.
    Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, Takatsu K, Konno K, Tobe K, Kanno H, Nakagawa T.
    J. Biol. Chem. 289(21)：14796-14811，2014.

2013

  1. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in HIF-1 alpha-dependent and HIF-1 alpha-independent manner in obese mice.
    Fujisaka S, Usui I, Ikutani M, Aminuddin, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K.
    Diabetologia. 56(6)：1403-1412，2013.
  2. Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairement in antigen presentation.
    Rachmawati NM, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
    Int. Immunol. 25(2)：117-128，2013.
  3. Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells.
    Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M.
    J. Immunol. 190(1)：195-204，2013.

2012

  1. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.
    Honda H, Nagai Y, Matsunaga T, Saitoh S, Akashi-Takamura S, Hayashi H, Fujii I, Miyake K, Muraguchi A, Takatsu K.
    J. Leukoc. Biol. 91(6)：967-976，2012.
  2. Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse.
    Nakamura T, Nishibu A, Yasoshima M, Tanoue C, Yoshida N, Hatta J, Miyamoto T, Nishii M, Yanagibashi T, Nagai Y, Takatsu K, Mochizuki T, Ogawa K.
    J. Dermatol. Sci. 66(2)：144-153，2012．
  3. The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
    Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama H, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y.
    Diabetes. 61(5)：1199-1209，2012.
  4. The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.
    Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.
    Int. Immunol. 24(6)：389-400，2012.
  5. Indentification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.
    Ikutatni M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K.
    J. Immunol. 188(2)：703-713，2012.
  6. Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice.
    Sasaki S, Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Tsuneyama K, Hirai Y, Takatsu K.
    Mol. Immunol. 49(4)：611-620，2012.

～2011

  1. Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaisumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs H, Miyawaki T.
    Clin. Immunol. 141(1)：111-120，2011.  
  2. Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat fed mice.
    Fujisaka S, Usui I, Kanatani Y, Ikutani M, Takasaki I, Tsuneyama K, Tabuchi Y, Bukhari A, Yamazaki Y, Suzuki H, Senda S, Aminuddin A, Nagai Y, Takatsu K, Kobayashi M, Tobe K.
    Endocrinology. 152(5)：1789-1799，2011.
  3. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.
    Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, Tsuneyama K, Nagai Y, Takatsu K, Urakaze M, Kobayashi M, Tobe K.
    Diabetes. 58(11)：2574-2682，2009.
  4. Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
    Tsukamoto Y, Nagai Y, Kariyone A, Shibata T, Kaisho T, Akira S, Miyake K, Takatsu K.
    Mol. Immunol. 46(7)：1278-1288，2009.
  5. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection.
    Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ, Borqhesi LA, Farrar MA, Kincade PW.
    Blood. 112(9)：3753-3761，2008.
  6. Tonic B cell activation by Radioprotective 105/MD-1 promotes disease progression in MRL/lpr mice.
    Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K.
    Int. Immunol. 20(7)： 881-891，2008.
  7. A protein associated with Toll-like receptor 4 (PRAT4A) is required for TLR-dependent immune responses.
    Takahashi K, Shibata T, Akashi-Takamura S, Kiyokawa T, Wakabayashi Y, Tanimura N, Kobayashi T, Matsumoto F, Fukui R, Kouro T, Nagai Y, Takatsu K, Saitoh S-I, Miyake K.
    J. Exp. Med. 204(12): 2963-2976，2007.
  8. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
    Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K,  Kincade PW.
    Immunity. 24(6)：801-812，2006.
  9. Tracing the first waves of lymphopoiesis in mice.
    Yokota T, J Huang, Tavian M, Nagai Y, Hirose J, Zuniga-Plucker JC, Peault B, Kincade PW.
    Development. 133(10)：2041-2051，2006.
  10. NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha.
    Igarashi H, Baba Y, Nagai Y, Jimi E, Ghosh S, Kincade PW.
    Int. Immunol. 18(5)：653-659，2006.
  11. Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin expressing cells.
    Yokota T, Kawakami Y, Nagai Y, Ma JX, Tsai JY, Kincade PW, Sato S.
    Stem Cells. 24(1)：13-22，2006.
  12. IL-6 blocks a discrete early step in lymphopoiesis.
    Maeda K, Baba Y, Nagai Y, Miyazaki K, Malykhin A, Nakamura K, Kincade PW, Sakaguchi N, Coggeshall KM.
    Blood. 106(3)：879-885，2005.
  13. The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD2 in antibody response to microbial membranes.
    Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K.
    J. Immunol. 174(11)：7043-7049，2005.
  14. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.
    Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y.
    J. Exp. Med. 201(3)：333-339，2005.
  15. Lipid A antagonist, lipid Ⅳa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
    Saitoh S, Akashi S, Yamada T, Tanimura N, Kobayashi M, Konno K, Matsumoto F, Fukase K, Kusumoto S, Nagai Y, Kusumoto Y, Kosugi A, Miyake K.
    Int. Immunol. 16(7)：961-969，2004.
  16. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than with MD-2 or CD14.
    Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, Nagai Y, Kusumoto Y, Fukase K, Kusumoto S, Adachi Y, Kosugi A, Miyake K.
    J. Exp. Med. 198(7)：1035-1042，2003.
  17. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
    Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O, Takeda K, Okochi H, Akira S, Tedder TF, Tamaki K.
    Blood. 102(4)：1374-1380，2003.
  18. Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution.
    Miyake K, Nagai Y, Akashi S, Nagafuku M, Ogata M, Kosugi A.
    J. Endotoxin Res. 8(6)：449-452，2002.
  19. Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
    Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, Miyake K.
    Nat. Immunol. 3(7)：667-672，2002.
  20. Requirement of MD-1 in cell surface expression of RP105/CD180 and B cell responsiveness to lipopolysaccahride.
    Nagai Y, Shimazu R, Ogata H, Akshi S, Sudo K, Yamasaki H, Hayashi S-I, Iwakura Y, Kimoto M, Miyake K.
    Blood. 99(5)：1699-1705，2002.
  21. Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.
    Akashi S, Nagai Y, Ogata H, Oikawa M, Fukase K, Kusumoto S, Kawasaki K, Nishijima M, Hayashi S, Kimoto M, Miyake K.
    Int. Immunol. 13(12)：1595-1599，2001.
  22. Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor4-MD-2.
    Akashi S, Ogata H, Kirikae F, Kirikae T, Kawasaki K, Nishijima M, Shimazu R, Nagai Y, Fukudome K, Kimoto M, Miyake K.
    Biochem. Biophys. Res. Commu. 268(1)：172-177，2000.
  23. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor4-MD-2 complex on mouse peritoneal macrophages.
    Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, Miyake K.
    J. Immunol. 164(7)：3471-3475，2000.
  24. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
    Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I, Rajewsky K, Kimoto M, Tarakhovsky A.
    J. Exp. Med. 192(1)：23-29，2000.
  25. MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor4.
    Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M.
    J. Exp. Med. 189(11)：1-6，1999.
  26. Differences in immune functions between human T-lymphotropic virus type 1 carriers and patients with adult T-cell leukemia/lymphoma.
    Funai N, Shimamoto Y, Yoshida S, Nagai Y, Nakazato S, Kohashi O.
    Clin. Immunol. Immunopathol. 80：325-332，1996.

Book・Review

Book

  1. Nagai Y，Watanabe Y, Honda H， Takatsu K：Chapter 8 Isoliquiritigenin: A unique licorice component that attenuates adipose tissue inflammation and fibrosis by targeting the innate immune sensors. In “Biological activities and action mechanisms of licorice ingredients” (ed. H. Sakagami), InTech, Zagreb, 2017, pp. 121－134（ISBN 978-953-51-3119-9）．
  2. Nagai Y，Honda H，Watanabe Y， Takatsu K：Chapter 30 Potential therapeutic natural products for the treatment of obesity-associated inflammation by targeting TLRs and inflammasomes. In “Chronic Inflammation –Mechanisms and Regulation-” (ed. M. Miyasaka and K. Takatsu), Springer Japan, Tokyo, 2016, pp. 379－397（ISBN 978-4-431-56068-5）.
  3. Nagai Y，Takatsu K：Section 2. Part E.26：Role of the immune system in obesity-associated inflammation and insulin resistance. In Nutrition in the Prevention and Treatment of Abdominal Obesity（ed. RR. Watson）．Elsevier/Academic Press，New York，2014，pp. 281－293．

Review

  1. Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.
    Yanagibashi T, Satoh M, Nagai Y, Koike M, Takatsu K.
    Cytokine, 98:59-70, 2017.
    https://www.ncbi.nlm.nih.gov/pubmed/28863833
  2. The TLR family protein RP105/MD-1 complex: A new player in obesity and adipose tissue inflammation.
    Nagai Y, Watanabe Y, Takatsu K.
    Adipocyte. 2(2) :61-66, 2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23805400
  3. Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance.
    Watanabe Y, Nagai Y, Takatsu K.
    Nutrients. 5(9): 3757-3778, 2013.
    http://www.ncbi.nlm.nih.gov/pubmed/24064574
  4. Interleukin 5 in the link between the innate and acquired immune response.
    Takatsu K, Kouro T, Nagai Y.
    Adv. Immunol., 101, 191－236, 2009.
    https://www.ncbi.nlm.nih.gov/pubmed/19231596
  5. Life before the pre-B cell receptor checkpoint: specification and commitment of primitive lymphoid progenitors in adult bone marrow.
    Pelayo R, Welner RS, Nagai Y, Kincade PW.
    Semin. Immunol. 18(1), 2－11, 2006.
    https://www.ncbi.nlm.nih.gov/pubmed/16310376
  6. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1.
    Miyake K, Ogata H, Nagai Y, Akashi S, Kimoto M.
    J. Endotoxin Res. 6(5), 389－391，2000.
    https://www.ncbi.nlm.nih.gov/pubmed/11521060
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