Research
Laboratory Philosophy
We harness enzymes as catalysts for chemical reactions to enable the production of valuable substances in the food, pharmaceutical, and agrochemical fields. Through sustainable manufacturing based on enzyme chemistry, we aim to contribute to the advancement of the enzyme chemical industry.
Research Direction - Integration and Expansion Across Fields Through Enzyme Chemistry -
In this laboratory, we explore and analyze the functions of biocatalysts based on organic chemistry. Furthermore, by combining metabolic pathway elucidation with protein engineering based on genomic and three-dimensional structural information, we advance the understanding and control of biological functions. Based on these findings, we develop new environmentally friendly synthesis and production processes targeting pharmaceuticals, agrochemicals, cosmetics, foods, and chemical products. By bridging basic research and applied research, we aim to create new interdisciplinary research fields.
Research Topics - Building Environmentally Harmonized Processes Utilizing Biological Functions -
Reactions using biocatalysts such as enzymes proceed under mild conditions and are characterized by low environmental impact. In this laboratory, we are working to develop sustainable material production processes through the discovery of new biocatalysts and the utilization of their functions.
Specifically, we conduct the following research:
- Exploration of novel biocatalysts through original screening using synthetic organic compounds
- Three-dimensional structural analysis and molecular modeling of enzymes and polysaccharides
- Modification of enzyme functions through directed molecular evolution and rational design
- Production of valuable substances by combining enzymatic reactions with chemical synthesis
Research Examples
Research Example 1: Analysis of Nitrile Metabolism in the Biological World
- Elucidation of metabolic pathways and modification based on enzyme evolution
- Search for super enzymes from unexplored enzyme resources (insects, etc.)
- Development toward toxin-free nitrile synthesis and fermentative production
Research Example 2: Demonstrating Enzyme-like Activity of Polysaccharides
- Exploration of novel polysaccharide catalysts from agricultural products and food biomass
- Higher-order structural analysis of polysaccharide catalysts and elucidation of catalytic mechanisms
- Modification of polysaccharide catalyst functions through chemical derivatization
What We Value in Learning
"We value a broad range of technical skills and quantitative ability."
・Target skills: biochemistry, enzyme purification, instrumental analysis, organic synthesis, microbial cultivation, genetic engineering, structural analysis, etc.
・Particularly emphasized: understanding of principles and practical skills in analytical and quantitative techniques (HPLC, GC, MS)
・Target organisms: animals, plants, and microorganisms (cross-disciplinary)
・Strengthening presentation and Q&A skills
Technical Skills We Value
