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THERAPEUTICALLY ACTIVE NANOMATERIALS FOR THE TREATMENT OF EYE DISEASES

are Murakami Lab’s main target. Such nanosmaterials are designed and created on the basis of a natural nanomaterial in our body, high-density lipoprotein (HDL). HDL is a ~10 nm material that consists mainly of a lipid-binding protein and a phospholipid membrane. HDL displays various biological activities during blood circulation, including cholesterol efflux capacity, anti-inflammatory activity, anti-oxidative activity. We are developing the nanomaterials with these increased activities as well as unnatural functions as eye drops.

Research

News & Topics

  • 09/02/2024
    Event
    Graduation Thesis Presentation
    Hayato TAKAGI, Yumemi Tajima, and Reina NAKANISHI made a poster presentation. Well done! Their long effort for preparing their presentation should be appreciated.
  • 29/12/2023
    Work
    Original Article
    The original article regarding drug loading into engineered high-density lipoprotein (HDL) nanoparticles was accepted for the publication in ACS Appl. Bio Mater.. Drug-loaded HDL nanoparticles were freeze-dryable and colloidally more stable than drug-loaded liposomes in an artificial tear solution.
  • 14, 16/11/2023
    Work
    Invited Lectures in Thailand
    Prof. Murakami gave invited lectures at the Departments of Pharmacy and Science in Chiang Mai University and at the department of Pharmacy in Mahidol University.
    "High-Density Lipoprotein Engineering for Eye Drop Treatment of Age-Related Macular Degeneration"
  • 18/10/2023
    Work
    Original Article
    The original article regarding comparative analysis of cell binding/internalization of variously engineered high-density lipoprotein nanoparticles in HeLa cells and BY-2 protoplasts was accepted for the publication in Genes Cells (sharable link). The eye drops were genetically engineered high-density lipoprotein (HDL) nanoparticles with corneal/conjunctival absorption-enhancing and neovasculature-targeting abilities. The HDL's biological activities of the nanoparticles were also analyzed.
  • 17/10/2023
    Event
    New Lab Members and Welcome Party
    Kiseki KOBAYASHI (B3), Kohei KOYAMA (B3), and Machiho NISHIDA (B3) have joined and started their graduation research, and a lunch party was held in the campus.
  • 29/08/2023
    Work
    Research Grant
    A research proposal entitled "Biomaterials for Prevention/Treatment of Eye Flail" by Hisaharu Ame Research Grant.
  • 29/08/2023
    Work
    Meeting Presentation
    Prof. Murakami gave an invited talk at 7th Toyama-Basel Joint Symposium (Invited).
    "High-Density Lipoprotein Engineering for Eye Drop Treatment of Age-Related Macular Degeneration"
  • 08/08/2023
    Work
    Original Article
    The original article regarding synthesis of butterfly-shaped gold nanoparticles and optical control of liquid-liquid phase transition with them was accepted for the publication in Small.
  • 03/08/2023
    Work
    Original Article
    The original article regarding developmeent of eye drops for the treatment of age-related macular degeneration was accepted for the publication in Adv. Therap. (open access). The eye drops were genetically engineered high-density lipoprotein (HDL) nanoparticles with corneal/conjunctival absorption-enhancing and neovasculature-targeting abilities. The HDL's biological activities of the nanoparticles were also analyzed.
  • 01/08/2023
    News
    Collabolation with Zeon Cooperation
    A joint research on microfluidic preparation of ~10 nm lipid nanoparticles has started.
  • 24/04/2023
    Work
    Research Grant
    A research proposal based on the joint research with Kyoto Univ Hospital was accepted by Kyoto University Open Innovation Institute.
  • 18/03/2023
    Event
    Graduation Ceremony
    Congratulation on your graduations. Good luck to Rumina, Ryo, and Rin!
  • 08/02/2023
    Event
    Graduation Thesis Presentation
    Tsukasa Ohashi, Haruka KURITA, and Rin ONAGA made a poster presentation. Well done! Their long effort for preparing their presentation should be appreciated.
  • 01/12/2022
    Work
    Meeting Presentation
    Ryo KAWAKAMI (M2) and Shiori SHIBUKAWA (M1) made poster presentations at the 45 th Annual Meeting of the Molecular Biology Society of Japan.
    "Neovasculature-Targeted Lipoprotein Mutant Eye Drops for the Treatment of Wet Age-Related Macular Degeneration in Mice" (Ryo)
    "Corneal Epithelial Cell Affinity and Posterior Eye Drug Delivery Ability of Lipoprotein Variants" (Shiori)
  • 26/10/2022
    Event
    New Lab Members and Welcome Party
    Hayato TAKAGI (B3), Yumemi TAJIMA (B3), and Reina NAKANISHI (B3) have joined and started their graduation research, and a lunch party was held for them in a park near the campus.
  • 19/10/2022
    Work
    Meeting Presentation
    Tsukasa (B4) made an oral presentation at the Annual Meeting of the Hokuriku Branch of the Society of Polymer Science, Japan .
    "Development of intraretinal DDS for treatment of early-stage age-related macular degeneration"
  • 12/06/2022
    Work
    Review Article
    The review article entitled "High-density lipoprotein as a therapeutic target of age-related macular degeneration" was published in BIO Clinica (Japanese). This article summarizes how high-density lipoprotein's biological activities counteract the pathogenesis of age-related macular degeneration in human and experimental animals.
  • 01/06/2022
    Work
    Meeting Presentation
    Prof. Murakami gave an invited talk at the 241th ECS meeting (digital).
    "Donor-Acceptor-Linked Molecules for Controlling the Membrane Potential of Living Cells"
  • 19/03/2022
    Event
    Graduation Ceremony
    Congratulation on your graduations. Good luck to Yui!
  • 09/02/2022
    Event
    Graduation Thesis Presentation
    Shiori SHIBUKAWA, Yui TSUKIO, and Yuu Mizukami made an oral presentation online. Well done! Their long effort for preparing their presentation should be appreciated.
  • 13/12/2021
    Work
    Meeting Presentation
    Rumina SHIMA made a poster presentation at the Materials Research Meeting 2021 (MRM2021) in Yokohama.
    "Blood Circulation Property of High-Density Lipoprotein in Zebrafish"
  • 14/10/2021
    Event
    Welcome Party
    A tea party was held for the new lab members after a photo session. The party was organized by the fourth-year students. Thanks!
  • 01/10/2021
    Event
    New Lab Members
    Tsukasa OHASHI (B3), Rin ONAGA (B3), and Haruka KURITA (B3) have joined and started their graduation research.
  • 01/10/2021
    Work
    Meeting Presentation
    Prof. Murakami gave an invited talk at ICFPE2021 (online).
    "Photo-Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecule"
  • 15/09/2021
    Work
    Meeting Presentation
    Ryosuke FUKUDA and Rumina SHIMA made an online poster presentation at the Toyama Basel Meeting 2021.
    "Potential of Engineered Lipoprotein Eye Drops for the Treatment of Age-Related Macular Degeneration (Fukuda)"
    "Comparative Analysis of the Pharmacokinetic Properties of High-Density Lipoprotein between Zebrafish embyos and mice (Shima)"
  • 14/09/2021
    Work
    Meeting Presentation
    Prof. Murakami gave an invited talk at the Annual Meeting on Photochemistry 2021 (online).
  • 01/08/2021
    Event
    New Lab Member
    Ryosuke FUKUDA has joined as a KAKENHI "Dynamic Excition" postdoc.
  • 30/07/2021
    Work
    Meeting Presentation
    Rumina SHIMA and Ryo KAWAKAMI made an online poster presentation at the 37th Annual Meeting of the Japan Society of Drug Delivery System.
  • 04/06/2021
    Work
    Meeting Presentation
    Prof. Murakami gave an invited talk at the 239th ECS meeting (online).
    "Optical Control of the Membrane Potential of Living Cells with Donor-Acceptor-Linked Molecules"
  • 01/04/2021
    News
    Research Position
    Tomohiro NOBEYAMA and Ryosuke FUKUDA were selected as JSPS postdoc (DC2).
  • 05/01/2021
    Work
    Patent
    Our application regarding lipoprotein mutant eye drops for the treatment of posterior eye diseases has filed in Japan (P6818264).
  • 01/12/2020
    News
    Research Grant
    The application for Grant-in-Aid for Transformative Research Areas, “Dynamic Exciton” (Project leader, Prof. Hiroshi Imahori of Kyoto Univ.) was accepted. Prof.Murakami joins as one of the PIs in this project. His research title is “Optical control of the plasma membrane functions by using dynamic exciton.
  • 16/11/2020
    Work
    Book Chapter
    The book that Tomohiro and Prof.Murakami were involved in was released. What they write was Chapter 24, "Phase Separation of Lipid Membranes and Their Future." It was Tomohiro's first time writing a book.
  • 07/10/2020
    Event
    Luncheon Party
    While maintaining social distance and protecting alcohol disinfection and mask, we held a welcome lunch party for Nargis(Postdoc) and Yui(B3) and Yu(B3) and Shiori(B3).
  • 29/09/2020
    Event
    PhD Conferment Ceremony
    The ceremony of Ph.D. degree conferment for Ryosuke and Tomohiro was held in the campus. Ryosuke and Tomohiro, congrats!
  • 19/08/2020
    Work
    Original Article
    The original article regarding the optical control of membrane potential with a donor-acceptor-linked molecule was accepted for the publication in Cell. Physiol. Biochem. This work is based on the joint research with Dr. Tomohiro NUMATA (Fukuoka Univ.).
  • 05/06/2020
    Work
    Original Article
    The original article of Tomohiro was accepted for the publication in Langmuir, which is already published on line. Congrats, Tomohiro!
Archive

Department of Pharmaceutical Engineering, Faculty of Engineering Toyama Prefectural University
Tatsuya Murakami Lab.

5180 Kurokawa, Imizu City, Toyama, 939-0398, Japan

Email : murakami(at))pu-toyama.ac.jp
Phone: 0766-56-7500 (within Japan),
+81-766-56-7500 (international)
Fax:0766-56-2498 (within Japan),
+81-766-56-2498 (international)