最近の発表論文 (2002〜)

1. H. Hori, T. Kajiura, Y. Igarashi, T. Furumai, K. Higashi, T. Ishiyama, M. Uramoto, Y. Uehara, and T. Oki, Biosynthesis of hibarimicins. I. 13C-labeling experiments. Journal of Antibiotics, 55, 46-52 (2002)

2. T. Kajiura, T. Furumai, Y. Igarashi, H. Hori, K. Higashi, T. Ishiyama, M. Uramoto, Y. Uehara, and T. Oki, Biosynthesis of hibarimicins. II. Elucidation of biosynthetic pathway by cosynthesis using blocked mutants. Journal of Antibiotics, 55, 53-60 (2002)

3. Y. Igarashi, T. Kajiura, T. Furumai, H. Hori, K. Higashi, T. Ishiyama, M. Uramoto, Y. Uehara, and T. Oki, Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants. Journal of Antibiotics, 55, 61-70 (2002)

4. T. Furumai, Y. Igarashi, H. Higuchi, N. Saito, and T. Oki, Kosinostatin, a quinocycline antibiotic with antitumor activity from Micromonospora sp. TP-A0468. Journal of Antibiotics, 55, 128-133 (2002)

5. Y. Igarashi, H. Higuchi, T. Oki, and T. Furumai, NMR analysis of quinocycline antibiotics: structure determination of kosinostatin, an antitumor substance from Micromonospora sp. TP-A0468. Journal of Antibiotics, 55, 134-140 (2002)

6. T. Sasaki, Y. Igarashi, N. Saito, and T. Furumai, Watasemycins A and B, new antibiotics produced by Streptomyces sp. TP-A0597. Journal of Antibiotics, 55, 249-255 (2002)

7. S-I. Cho, H. Fukazawa, Y. Honma, T. Kajiura, H. Hori, Y. Igarashi, T. Furumai, T. Oki, and Y. Uehara, Effects of hibarimicins and hibarimicin-related compounds produced by Microbispora on v-Src kinase activity and growth and differentiation of human myeloid leukemia HL-60 cells. Journal of Antibiotics, 55, 270-278 (2002)

8. Y. Igarashi, A. Sekine, H. Fukazawa, Y. Uehara, K. Yamaguchi, Y. Endo, T. Okuda, T. Furumai, and T. Oki, Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213. Journal of Antibiotics, 55, 371-376 (2002)

9. 五十嵐康弘,葭田隆治,古米保, 植物由来放線菌が生産する植物生理活性物質  植物の成長調節, 37, 63-68 (2002)

10. Y. Igarashi, T. Iida, T. Sasaki, N. Saito, R. Yoshida, and T. Furumai, Isolation of actinomycetes from live plants and evaluation of antiphytopathogenic activity of their metabolites. Actinomycetologica, 16, 9-13 (2002)

11. Y. Igarashi, T. Iida, R. Yoshida, and T. Furumai, Pteridic acids A and B, novel plant growth promoters with auxin-like activity from Streptomyces hygroscopicus TP-A0451. Journal of Antibiotics, 55, 764-767 (2002)

12. T. Furumai, K. Eto, T. Sasaki, H. Onaka, N. Satio, and Y. Igarashi, TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598. Journal of Antibiotics, 55, 873-880 (2002)

13. T. Sasaki, Y. Igarashi, M. Ogawa, and T. Furumai, Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity of 6-substituted indoles. Journal of Antibiotics, 55, 1009-1012 (2002

14. H. Onaka, S. Taniguchi, Y. Igarsahi, and T. Furumai, Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans, Journal of Antibiotics, 55, 1063-1071 (2002).

15. H. Onaka, S. Taniguchi, Y. Igarashi, and T. Furumai, Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevarieria aerocolonigenes ATCC 39243, Bioscience, Biotechnology, and Biochemistry, 67, 127-138 (2003).

16. Y. Igarashi, K. Futamata, T. Fujita, A. Sekine, H. Senda, H. Naoki, and T. Furumai, Yatakemycin, a novel antifungal antibiotic produced by Streptomyces sp. TP-A0356, Journal of Antibiotics, 56, 107-113 (2003).

17. H. Minamiyama, M. Shimizu, H. Kunoh, T. Furumai, Y. Igarashi, H. Onaka, and R. Yoshida, Multiplication of isolate R-5 of Streptomyces galbus on rhododendron leaves and its production of cell wall-degrading enzymes, Journal of General Plant Pathology, 69, 65-70 (2003).

18. Y. In, H. Ohishi, T. Ishida, and Y. Igarashi, Concerted interaction between conjugated double bond CHs and multiple OHs in polyene macrolide antibiotic chainin: weak =C-H interactions responsible for intrinsic molecular assembly, Chemical Communications, 1692-1693 (2003).

19. T. Furumai, T. Yamakawa, R. Yoshida, and Y. Igarashi, Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. I. Screening, taxonomy, fermentation, isolation and biological properties, Journal of Antibiotics, 56, 700-704 (2003).

20. Y. Igarashi, T. Iwashita, T. Fujita, H. Naoki, T. Yamakawa, R. Yoshida, and T. Furumai, Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. II. Physico-chemical properties and structure determination, Journal of Antibiotics, 56, 705-708 (2003).

21. E.A. Aremu, T. Furumai, Y. Igarashi, Y. Sato, H. Akamatsu, M. Kodama, and H. Otani, Specific inhibition of spore germination of Alternaria brassicicola by fistupyrone from Streptomyces sp. TP-A0569, Journal of General Plant Pathology, 69, 211-217 (2003).

22. F. Hiramoto, N. Nomura, T. Furumai, T. Oki, and Y. Igarashi,  Apoptosis-like cell death of Saccharomyces cerevisiae induced by a mannose-binding antifungal antibiotic, pradimicin, Journal of Antibiotics, 56, 768-772 (2003).

23. J.P. Parrish, D.B. Kastrinsky, S.E. Wolkenberg, Y. Igarashi, and D.L. Boger, DNA alkylation properties of yatakemycin, Journal of American Chemical Society, 125, 10971-10976 (2003).

24. H. Onaka, S. Taniguchi, H. Ikeda, Y. Igarashi, and T. Furumai, pTOYAMAcos, pTYM18, and pTYM19, actinomycete-Escherichia coli integrating vectors for heterologous gene expression, Journal of Antibiotics, 56, 950-956 (2003).

25. N. Nakajima, T. Isobe, S. Irisa, and M. Ubukata, Stereochemistry: synthesis of 1,4-diazepan-3-one analogues by reductive amination approach, Heterocycles, 59, 107-113 (2003).

26. F. Hiramoto, N. Nomura, T. Furumai, Y. Igarashi, and T. Oki, Pradimicin-resistance of yeast is caused by a point mutation of the histidine-containing phosphotransfer protein Ypd1, J. Antibiotics, 56, 1053-1057 (2003).

27. Y. Igarashi, Y. Yabuta, and T. Furumai, Determination of the absolute configuration of synerazol, J. Antibiotics, 57, 537-540 (2004).

28. M. Shimizu, Y. Igarashi, T. Furumai, H. Onaka, and H. Kunoh, Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites, J. Gen. Plant Pathol., 70, 66-68 (2004).

29. Y. Igarashi, Y. Yabuta, A. Sekine, K. Fujii, K. Harada, T. Oikawa, M. Sato, T. Furumai, and T. Oki, Directed biosynthesis of fluorinated pseurotin A, synerazol and gliotoxin, Journal of Antibiotics, 57, 748-754 (2004).

30. 尾仲宏康・谷口真市・五十嵐康弘・古米 保 Award for Excellence to authors publishing in Bioscience, Biotechnology, and Biochemistry. Lechevalieria aerocolonigenes  ATCC39243のレベッカマイシン生合成遺伝子群の解析 日本農芸化学会誌 vol.78, No.9, 48-49 (2004)

31. H. Onaka, Characterization of the biosynthetic gene cluster of goadsporin which promotes secondary metabolism and sporulation in actinomycetes, Report of the Noda Institute for Scientific Research, 48, 127-128 (2004).

32. H. Onaka, Studies on goadsporin : mechanism of its action on the induction of secondary metabolism and sporulation in streptomycetes, and its application, The Waksman Foundation of Japan INC. Report of Researches in 2003, 1-11 (2004).

33. F. Hiramoto, N. Nomura, T. Furumai, Y. Igarashi, and T. Oki, Pradimicin resistance of yeast is caused by a mutation of the putative N-glycosylation sites of osmosensor protein Sln1, Bioscience, Biotechnology, and Biochemistry, 69, 238-241 (2005).

34. Y. Ikeda, H. Nonaka, T. Furumai, and Y. Igarashi, Cremastrine, a novel pyrrolizidine alkaloid from Cremastra appendiculata, Journal of Natural Products, 68, 572-573 (2005).

35. Y. Igarashi, K. Ootsu, H. Onaka, T. Fujita, Y. Uehara, and T. Furumai, Anicemycin, a new inhibitor of anchorage-independent growth of tumor cells from Streptomyces sp. TP-A0648, Journal of Antibiotics, 58, 322-326 (2005).

36. Y. Igarashi, S. Miyanaga, H. Onaka, M. Takeshita, and T. Furumai, Revision of the structure assigned to the antibiotic BU-4664L from Micromonospora, Journal of Antibiotics, 58, 350-352 (2005).

37. Y. Ikeda, H. Nonaka, T. Furumai, H. Onaka, and Y. Igarashi, Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674, Journal of Natural Products, 68, 1061-1065 (2005).

38. 尾仲宏康 放線菌由来複素環抗生物質の生合成研究および新規物質創製への展開 長瀬科学技術振興財団研究報告集2004年度版 vol.15, 77-86 (2005)

39. Y. Igarashi, Y. In, T. Ishida, T. Fujita, T. Yamakawa, H. Onaka, and T. Furumai, Absolute configuration of TPU-0043, a pentaene macrolide from Streptomyces sp, Journal of Antibiotics, 58, 523-525 (2005).

40. Y. Ikeda, T. Furumai, and Y. Igarashi, Nocardimicins G, H and I, siderophores with muscarinic M3 receptor binding inhibitory activity from Nocardia nova JCM 6044, Journal of Antibiotics, 58, 566-572 (2005).

41. H. Onaka, S. Asamizu, Y. Igarashi, R. Yoshida, and T. Furumai, Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biotynthesis of Streptomyces sp. TP-A0274, Bioscience, Biotechnology and Biochemistry, 69 (9), 1753-1759 (2005).

42. H. Onaka, M. Nakaho, K. Hayashi, Y. Igarashi, and T. Furumai, Cloning and characterization of goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584, Microbiology,151 : 3923-3933 (2005).

43. S. Asamizu, Y. Kato, Y. Igarashi, T. Furumai, and H. Onaka, Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis, Tetrahedron Letters, 47 : 473-475 (2006).

44. S. Miyanaga, T. Obata, H. Onaka, T. Fujita, N. Saito, H. Sakurai, I. Saiki, T. Furumai, Y. Igarashi, Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861, Journal of Antibiotics, 59: 698-703 (2006)

45. H. Onaka, Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds, Actinomycetologica, 20: 62-71 (2006)

戻る